User blog comment:Gekkou30/Epic Battle Solid Snake vs Batman/@comment-3277247-20130811221406/@comment-1672596-20130812023417

Actually, in the DCAU, Joker actually did attempt to nuke Gotham City. That, as well as the Batman/Captain America crossover, where he and Red Skull attempted to nuke I think New York City before their falling out.

And I'd argue that his most sick joke in the Arkham series (his 4th of July massacres where he blacked out the city and had everyone watch fireworks that were laced with Joker venom when they exploded, a heinous enough joke that Batman had to personally escort him through a sea of bodies to the restricted ward of Batman Arkham Asylum) is comparable to a nuke going off.