Board Thread:General Discussion/@comment-27058497-20151012024826/@comment-2112031-20151012090434

Pretty unlikely, it was established in MGS4 that Snake only had about a year left to live at most and that flesh and blood operatives were becoming obsolete in a world with increasing cybernetic security (as shown in Rising).

The novelisation of MGS4 also depicts Snake as dying with a smile on his face, surrounded by friends, sometime after the events of MGS4. I think after everything that happened to him, he deserves to live a quiet and peaceful life in what little time he has left.

I do think, however, that they could remake the events of MG1 and MG2:SS. Expand the story and tie everything together. That way we could once again play as snake without having to ruin his happy ending.