Board Thread:News and Announcements/@comment-4016602-20131013160432/@comment-1672596-20131020022910

Bern Yoshidome wrote: The injection that Ishmael gave to Big Boss could be Nanomachines, so that the masked kid could make illusions, remembering that Johnny, who didn't have Nanomachines in his body wasn't affect to Screaming Mantis at MGS4.

Nanomachines haven't even been invented at the time of this game. Heck, MGS1 and even MGS4 to some extent made it a pretty big deal that nanomachines only came about during the turn of the century.