Board Thread:General Discussion/@comment-66.56.44.237-20130617084327/@comment-4913740-20140404142403

Not only that, but they could also be the first experiments in gene therapy, which is the process through which the Genome soldiers later in MGS1 would be injected with Big Boss' genes (or have their nucleotide alignment rearranged to resemble Big Boss' DNA) in order to improve them as soldiers.

That means these soldiers could very well be the first to have their DNA altered to be similar to Big Boss. And he will likely end up fighting them.