Thread:Bluerock/@comment-3184244-20180819030607/@comment-1504072-20180821224327

Humans are eukaryotes, not prokaryotes, so your example is not applicable. The cloning process is achieved through somatic cell nuclear transfer. In this article, the section "Reproductive cloning" refers to cloned offspring.

The Snake clones shouldn't be described as siblings to Big Boss, because that is not the personal relationship that the characters have to one another, and it is never really presented that way in the story. Also, family relationship titles mean so much more, among humans, than the mere basis in "nature/biology."

As for Kojima's comments, it's clear to me that he's referring more to Solid Snake on a personal level, being a cold, less emotive character than Big Boss.