Board Thread:Questions and Answers/@comment-25090680-20160918142941/@comment-2112031-20160919101353

I suggest you play it the way you personally think will most benefit your enjoyment. I would personally suggest chronological order, mostly because MGS V is a rather disappointing conclusion to the series, with MGS 4 being much more appropriate as a finale and MGR being a pretty decent continuation.

There are plenty of retcons here and there, but most of them are retcons about stuff that was only mentioned in manuals (e.g. Big Boss losing his eye in the late 1980s, Gray Fox being the last person to have the "Fox" codename, as opposed to being the only one).

The only one that really jumped out at me was when Liquid Ocelot stated that Big Boss was in his late 50s when his sons were created, but was later stated to have been 37 at the time. I personally chalk that one up to Liquid not knowing Big Boss' actual age due to deliberate misinformation.