Board Thread:General Discussion/@comment-1918136-20131106045017/@comment-3060460-20140414194655

The only reason Naomi said FOXDIE would target his loved ones is because the virus itself mutated within the 9 years between MGS2 and 4, plus Big Boss stated FOXDIE re-mutated in MGS4 because of him and he no longer had to worry about it targeting Sunny, Otacon, Meryl(etc) since he wouldn't live long enough for it to happen.