Board Thread:News and Announcements/@comment-4016602-20131013160432/@comment-4016602-20131013165137

Only Expeculation:

The XOF attacked MSF for, besides put Big Boss down, They could capture Dr. Strangelove to make the Patriots' AI and Dr. Huey Emmerich to make a bipedal tank (Meta Gear).

After the destruction of Mother Base, Big Boss went to a hospital in the United Kingdom, along with Kaz Miller and HIM (if the guy that Kaz mentioned was a character). At the end of 1st MGSV trailer, a character that we think that is Big Boss awake from a coma of 9 years, well, Big Boss was in a coma at the end of Ground Zeroes, but do not know for how long, and the man who wakes up at the end of the video can not be said that Big Boss is because we do not see his face or hear his voice. During the Invasion of XOF, Ishmael injected digoxin at "Big Boss", but I think that what he injected was a hallucinogen, that's why he saw a man like Volgin Burning and a boy similar as Psycho Mantis.